Vascular Endothelial Growth Factor Receptor-2

A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.

Also Known As:

Vascular Endothelial Growth Factor Receptor 2; Fetal Liver Kinase-1; Flk-1 Protein; Flk-1 Receptor Tyrosine Kinase; KDR Tyrosine Kinase; Kinase Insert Domain Receptor; VEGF Receptor Flk-1; VEGF Receptor KDR; Fetal Liver Kinase 1; Flk 1 Protein; Flk 1 Receptor Tyrosine Kinase; Flk-1, VEGF Receptor; KDR, VEGF Receptor; Tyrosine Kinase, KDR; VEGF Receptor Flk 1; VEGFR-2

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        Vascular Endothelial Growth Factor Receptors: 3429
        Vascular Endothelial Growth Factor Receptor-2: 2246
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        Vascular Endothelial Growth Factor Receptors: 3429
        Vascular Endothelial Growth Factor Receptor-2: 2246
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Vascular Endothelial Growth Factor Receptors: 3429
        Vascular Endothelial Growth Factor Receptor-2: 2246
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        Vascular Endothelial Growth Factor Receptors: 3429
        Vascular Endothelial Growth Factor Receptor-2: 2246

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Disease

Drug/Important Bio-Agent (IBA)